ODCs

Cytoscape Web

Click node...

1 OMIM reference -
2 associated genes
21 signs/symptoms

PROTEIN INTERACTIONS: 1

Proteus-like syndrome

1 OMIM reference -
1 associated gene
22 signs/symptoms

Desmoid tumor

Proteus-like syndrome

APC	(UniProt - OMIM)		PTEN	(UniProt - OMIM)
CTNNB1	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	CTNNB1	(0.49)	PTEN

Citations in the biomedical literature:

Desmoid tumor		Proteus-like syndrome
	Synonym(s): - Aggressive fibromatosis - Desmoid type fibromatosis		Synonym(s): - Cohen-Hayden syndrome

	Classification (Orphanet): - Rare oncologic disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare genetic disease - Rare oncologic disease - Rare skin disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: adolescence / young Average age of death: normal Type of inheritance: sporadic		Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - No MeSH references

Desmoid tumor		Proteus-like syndrome
	Very frequent - Anomalies of the abdominal wall - Fibromatosis / bone fibroma - Muscle anomalies - Soft tissue sarcoma / cancer / tumor / liposarcoma / myosarcoma - Subcutaneous nodules / lipomas / tumefaction / swelling Frequent - Acute abdominal pain / colic - Myalgia / muscular pain - Polyposis of the bowel / colon / intestine Occasional - Articular / joint pain / arthralgia - Bladder and ureter anomalies - Early death / lethality - Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia - Intestinal obstruction / ileus - Malabsorption / chronic diarrhea / steatorrhea - Megaureter / hydronephrosis / pyeloureteral junction syndrome - Osteolysis / osteoclasia / bone destruction / erosions - Restricted joint mobility / joint stiffness / ankylosis - Retinitis pigmentosa / retinal pigmentary changes - Sepsis severe / septicemia - Skin tumors / lumps / epidermal cysts - Thoracic / chest pain		Very frequent - Asymmetry of the body / hemiatrophy / hemihyperthrophy - Capillary hemangioma / nevus / naevus flammeus / port-wine stain - Conjunctival tumor / epibulbar dermoid - Dental malocclusion - Exostoses - Genu recurvatum - Intellectual deficit / mental / psychomotor retardation / learning disability - Irregular / in bands / reticular skin hyperpigmentation - Lower limb asymmetry / hemiatrophy / hemihypertrophy - Myopia - Pigmented naevi / naevus pigmentosus / lentigo - Pupillary anomalies / mydriasis / myosis / tonic pupil - Xanthomas / lipomas Frequent - Cataract / lens opacification - Communicating hydrocephaly - Heterochromia / mixed colouring of iris - Macrocephaly / macrocrania / megalocephaly / megacephaly - Parathyroids anomalies - Prognathism / prognathia - Retinal detachment - Shagreen patch - Varices / varicous veins / venous insufficiency